Profile

We use a range of model systems to study what happens as cells and organisms age. In particular, we are very interested in the role of a protein called WRN that helps to stop cells ageing prematurely. We are studying the effect of mutating this gene in worms and flies, to explain why people with a mutation in WRN show many of the signs of normal ageing. We also have a long term project to age human cells in the lab and measure biochemical changes with age.

I run my own experiments looking at human cell ageing and collaborate with colleagues on fly and worm ageing. I also teach undergraduate students and supervise graduates. and research staff. There is no such thing as a typical day – they are all very different from each other but very busy and good fun.